Gata1 transcription factor

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August undefined, 2024

WebAug 2, 2024 · Our findings show that GATA1 and NF-Y activate γ-globin expression, consolidating previous studies implicating these transcription factors and their respective cis elements in the expression of ... WebApr 21, 2024 · Master regulators, such as the hematopoietic transcription factor (TF) GATA1, play an essential role in orchestrating lineage commitment and differentiation. However, the precise mechanisms by which such TFs regulate transcription through interactions with specific cis -regulatory elements remain incompletely understood.

髓系造血分化核心转录因子研究进展 - ResearchGate

WebInterestingly, we found GATA1 was the transcription factor (TF) of HNF1A-AS1. Previously, GATA1 has been unveiled to be overexpressed and also function as a TF in breast carcinomas. 34,35 Through mechanism experiments, we proved the interaction of GATA1 with HNF1A-AS1 promoter and also discovered that HNF1A-AS1 expression … WebOct 22, 2024 · GATA transcription factors are evolutionarily conserved among animals, plants and fungi. Vertebrates possess six paralogs, classified into two subfamilies based … dshs staff directory washington

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WebHuman Molecular Genetics, 2002, Vol. 11, No. 2 149 Direct binding of the GATA1 mutants to DNA, studied as previously described by Freson et al. (15), was not disturbed (Fig. … WebMar 30, 2024 · GATA-1, the founding member of a distinctive family of transcription factors, is expressed predominantly in erythroid cells and participates in the expression of numerous erythroid cell-expressed genes. GATA-binding sites are found in the promoters and enhancers of globin and nonglobin erythroid genes as well as in the α-and β-globin … WebGATA-1 is a transcription factor that is essential for erythroid cell development and is generally absent in other cell types (140). GATA-1 recognizes the sequence GATA found … dshs state st tacoma

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WebThe GATA1 protein is also important for the maturation of several types of white blood cells that help fight infection, including eosinophils, mast cells, and dendritic cells. Two … WebJan 9, 2024 · The transcription factor GATA1 regulates the expression of essential erythroid and megakaryocytic differentiation genes through binding to the DNA consensus sequence WGATAR. The GATA1 protein has … dshs sun safety policyWebGATA1 is a transcription factor closely linked with erythropoiesis and megakaryopoiesis. The Val205Met mutation in the GATA1 gene underlies a CDA with dyserythropoiesis and … dshs state street tacoma

"WebRegulation of gene expression during the ontogeny of haematopoiesis in the human fetal bone marrow is poorly understood. Studies in mice demonstrated that GATA-1, -2 and -3 play pivotal roles in haematopoiesis. In this study, we identified GATA-1-, GATA-2- and GATA-3-expressing cells in bone marrow … " - Gata1 transcription factor

Gata1 transcription factor

Transcriptional regulation of autophagy and its implications in …

WebTranscriptional activator or repressor which serves as a general switch factor for erythroid development ( PubMed: 35030251 ). It binds to DNA sites with the consensus sequence … Webnote that the transcription factor NF-Y binding to the CCAAT site within the Gﬁ-1B promoter plays a critical role in GATA-1 responsiveness. In summary, we have …

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WebExample of a reduction of function mutation: GATA1 The GATA1 transcription factor regulates erythroid gene expression. Some mutations give rise to the X-linked diseases of Thalassemia and Thrombocytopenia. The GATA1 protein contains a number of residues which are conserved across highly divergent organisms. WebSpecific research interests include the role of the N-terminal domain of the GATA1 transcription factor and the genetic contributions toward the …

WebApr 21, 2024 · GATA1 is the master erythroid transcription factor (TF). It is a 413-amino-acid-long protein with 2 zinc finger (ZnF) domains mapping to the C-terminal half of the … WebNov 25, 2024 · Abstract. GATA1 is considered as the “master” transcription factor in erythropoiesis. It regulates at the transcriptional level all aspects of erythroid maturation and function, as revealed by gene …

WebGATA transcription factors are required for the differentiation of diverse cell types in several species. Recent evidence suggests that their biologic activities may be modulated through interaction with multitype zinc finger proteins, such as Friend of GATA-1 (FOG) and U-shaped (Ush). In cell culture, FOG cooperates with the hematopoietic ... Web2 days ago · TFEB (transcription factor EB) is a one of the microphthalmia (MiT/TFE) transcription factors belonging to the basic helix-loop-helix leucine-zipper family, and is …

WebGATA transcription factors comprise a family of zinc finger proteins that bind the consensus DNA sequence (T/A)GATA (A/G). There are six known members of the …

WebThe transcription factor GATA1 coordinates timely activation and repression of megakaryocyte gene expression. Loss of GATA1 function results in excessive megakaryocyte proliferation and disordered te dshs structureWebMar 9, 2024 · Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of transcription. However, they are also detected in anucleated platelets. The transcription factors RUNX1, GATA1, STAT3, NFκB, and PPAR have been widely reported to play key roles in the pathophysiology of platelet hyper-reactivity, thrombosis, … commercial match fishingWeb作用，转录因子（transcription factor，TF）在造血分化过程中发挥了核心调节作用，在多系分化方向关键点控制HSPC分化命运。 dshs supported livingWebAug 1, 2012 · GATA binding protein 1 (GATA1, GenBank ID: NM_002049) is a key haematopoietic transcription factor with a pivotal role in differentiation of the erythroid, megakaryocyte, eosinophil and mast cell lineages[].The GATA1 gene produces at least two protein isoforms—the well characterised GATA1 full-length (GATA1FL) isoform and a … commercial masonry suppliers near meWebMar 21, 2024 · Entrez Gene Summary for GATA1 Gene. This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role … dshs sunnyside wa commercial maytag repairman near meWebApr 13, 2024 · The GATA transcription factor family Mammalian genomes encode six structurally related members of the GATA family, which function as tissue-specific master … dshs support services