Sponge lncrna

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August undefined, 2024

Web9 Apr 2024 · The lncRNA regulator of Akt signaling associated with HCC and RCC (LNCARSR; lnc-TALC) overexpression was shown to be accountable for temozolomide (TMZ) resistance and associated with glioblastoma recurrence. LNCARSR can sponge miR-20b-3p to enhance c-Met expression and improve chemoresistance to TMZ . WebLncRNA H19 participates as a sponge of miR-17, which targets STAT3 102 and miR-196b, a miRNA repressor of LIN28B whose reduced activity enhances tumor progression. 103 Importantly, upregulation of oncogenic lncRNAs that modify Wnt/β-catenin pathways is related to tumor growth in several cases, as occurs for SNHG1 104 and FOXD2-AS1. 105 …

Decrypting the crosstalk of noncoding RNAs in the ... - Springer

Web“Molecular sponge” is that lncRNA competitively binds to microRNA based on base complementary pairing, thereby inhibiting the binding of microRNA to its target gene, thereby up-regulating the expression of the microRNA target gene and making it function. 36 In previous study, Zhou et al found that TRIM52-AS1 could sponge miR-514a-5p to ... east paulding pediatrics wellstar

LMSM: A modular approach for identifying lncRNA related miRNA …

Web15 Dec 2024 · In this study, lncRNA DLEU2 was found to act as a miR-181a sponge and inhibited skeletal muscle regeneration and differentiation. The lncDLEU2-miR-181a-SEPP1 … WebThis competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC … Web1 Jan 2024 · LncRNA LINC00662 activates Wnt/β-catenin signaling in HCC cells and further promotes HCC cell proliferation, cell cycle, and invasion and represses HCC cell apoptosis … east paulding middle school ga

RBPSponge: genome-wide identification of lncRNAs that …

miRNA sponges: soaking up miRNAs for regulation of gene …

Web1 Nov 2024 · RBPSponge identifies the occurrences of RBP-binding sites and CLIP peaks on lncRNAs, and enables users to run statistical analyses to investigate the regulatory … Web15 Dec 2024 · In this study, lncRNA DLEU2 was found to act as a miR-181a sponge and inhibited skeletal muscle regeneration and differentiation. The lncDLEU2-miR-181a-SEPP1 pathway inhibits muscle differentiation and regeneration and can be used as a novel therapeutic target for the treatment of age-associated sarcopenia. culver way sandownWeb18 Jun 2024 · LncRNA is a kind of non-encoding RNA transcripts >200 nucleotides in length 5, many of which show cell type-specific expression 6, 7. Emerging studies have shown … east paulding pediatrics hiram ga

"Web4 Sep 2024 · Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs … " - Sponge lncrna

Sponge lncrna

lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and …

Web21 Jul 2024 · The regulation of lncRNA at transcriptional and posttranscriptional levels is mainly through the following mechanisms. As a molecular sponge, lncRNA inhibits the inhibition of target genes by binding and sponging miRNAs. For example, lncRNA SOX21-AS1 blocks the inhibition of the target gene VDAC1 by miR-7 via sponging miR-7 . LncRNA … WebLncRNA NEAT1 Acts as miR-148b-3p Sponge to Regulate ROCK1 to Inhibit Cell Proliferation and Invasion. We co-transfected plasmids to verify the relationship of LncRNA NEAT1 …

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Web12 Jul 2024 · Through regulating the interaction among DNA, protein and RNA, LncRNA (Human body) drives the biological functions of various cancer cells (Human Tumor) to change and plays a role in promoting tumor growth. 10, 11 Nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) is over-expressed in a variety of tumors (Human Tumor), 12, … Web11 May 2024 · Therefore, FGD5-AS1 should be a versatile and pleiotropic master regulator of gene expression as a sponge lncRNA for miRNAs. To validate the lncRNA–miRNA–mRNA regulatory relationship that we identified in heart tissues with TOF, we selected two miRNAs for each of the FGD5-AS1 targets: PTEN (hsa-miR-107 and hsa-miR-320-3p) and SMAD4 …

Web3 Jun 2016 · spongeScan – a graphical web tool for detecting microRNA binding elements in lncRNA sequences Posted by: lncRNA Administrator in Online Tools, Prediction June 3, 2016 0 7,415 Views Non-coding RNA transcripts such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are important genetic regulators. Web21 Aug 2024 · The “sponge” activity of lncRNAs can be scrutinized with the use of experimentally supported miRNA–mRNA pairs from TarBase and in silico characterized miRNA targets from microT-CDS . miRNA–lncRNA interactions can be enhanced with predicted pairs from LncBase v2 .

Web19 May 2016 · spongeScan is a web resource to find highly enriched MRE binding sites in lncRNAs. Users must provide the lncRNA transcript sequences in a FASTA file. These … Web22 Dec 2024 · Depending on their localization and their specific interactions with DNA, RNA and proteins, lncRNAs can modulate chromatin function, regulate the assembly and …

WebFor instance, lncRNA ATB targets the miR‐200b/Kindlin‐2 axis to facilitate the malignancy of ESCC. 18 LncRNA TUG1 enhances cisplatin resistance by regulating Nrf2 in ESCC. 19 LncRNA LINC00675 represses ESCC development and EMT via blocking Wnt/β‐catenin signaling. 20 FAM225A is a new lncRNA and has only been explored in nasopharyngeal …

Web21 Mar 2024 · Nrf2-lncRNA existed in the cytoplasm, suggestive of its function as a competing endogenous RNA [ceRNA, microRNA (miRNA) sponge]. Nrf2-lncRNA served as a ceRNA for polo-like kinase (Plk) 2 and cyclin-dependent kinase inhibitor 1 (p21 cip1) through binding of miRNA 128 and miRNA 224, inducing Plk2/Nrf2/p21 cip1 complexation for Nrf2 … east paulding middle school staffWebMechanistically, ASB16-AS1 served as a sponge for miR-760 and positively modulated the expression of its target HDGF. Finally, inhibiting miR-760 and restoring HDGF expression … east paulding middle school canvasWebMajority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular RNAs, circular (circ)RNAs include a large family of noncoding (nc)RNAs that lack the 5' or … culverwells robertsbridge used carsWeb21 Mar 2024 · Heat responsive lncRNA (TCONS_00048391) is an eTM for bra-miR164a, that could be a sponge for miRNA binding and may be a competing endogenous RNA (ceRNA) for the target gene NAC1 (Bra030820),... east paulding pediatrics faxWeb1 Jan 2024 · LncRNA-HOTAIR acts as a miR-148a sponge to positively regulate Snail2 expression, enhance cell invasion and metastasis, and promote the EMT in EC. LncRNA-HOTAIR may play an important role in tumor development and progression and represent a novel therapeutic target for EC. east paulding middle school websiteWeb15 Mar 2016 · Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization … east paulding middle school principalWebEmerging evidence demonstrates that circRNA functions as an miRNA sponge, thus regulating a series of physiological activities. We next predicted the target miRNAs of … culver welcome center oshkosh